《英文msh词典》Alkylating Antineoplastic Agents
[入口词] Alkylating Antineoplastic Agents
[主题词] Antineoplastic Agents,Alkylating
[中文释义] 烷基化抗肿瘤药
[英文释义] A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups,that after metabolism,can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA,Drug Evaluations Annual,1994,p2026)