《英文msh词典》Antibody OKT3,Monoclonal
[入口词] Antibody OKT3,Monoclonal
[主题词] Muromonab-CD3
[药动学] Immunosuppressive Agents
[英文释义] Anti-CD3 monoclonal antibody that exerts immunosuppressive effects by inducing peripheral T-cell depletion and modulation of the T-cell receptor complex (CD3/Ti). This biochemically purified IMMUNOGLOBULIN G is obtained through the fusion of mouse myeloma cells to lymphocytes from immunized animals to produce hybridomas that secrete specific antibodies to the T3 (CD3) antigens of human T-lymphocytes. It is often used as an immunosuppressive agent in transplantation.