《英文msh词典》Antigens,CD42b
[同义词] Antigens,CD42b
[主题词] Platelet Glycoprotein GPIb-IX Complex
[中文释义] 抗原,CD42b
[英文释义] Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides,GPIb alpha,GPIb beta,and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.