《英文msh词典》Leukocyte Function Associated Antigen-1
[同义词] Leukocyte Function Associated Antigen-1
[主题词] Lymphocyte Function-Associated Antigen-1
[中文释义] 白细胞功能相关抗原1
[英文释义] An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (ANTIGENS,CD18) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS,B-CELLS,and GRANUALOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation,helper T-cell interactions,and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. INTRACELLULAR ADHESION MOLECULE-1 has been defined as a ligand for lymphocyte function-associated antigen-1.