《英文MSH词典》MK 733
[入口词] MK 733
[主题词] Simvastatin
[药动学] Hydroxymethylglutaryl-CoA Reductase Inhibitors
[英文释义] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES),which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS,it increases breakdown of LDL-cholesterol (LIPOPROTEINS,LDL CHOLESTEROL).