《英文msh词典》Receptor,Stem Cell Factor
[同义词] Receptor,Stem Cell Factor
[主题词] Proto-Oncogene Protein c-kit
[中文释义] 受体,干细胞因子
[英文释义] A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic,gonadal,and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEIN C-KIT are associated with PIEBALDISM,while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.