《英文msh词典》Sedoval
[入口词] Sedoval
[主题词] Thalidomide
[药动学] Teratogens
[英文释义] A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic,but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes,and modulates other cytokine action.