《英文msh词典》ddNus
[入口词] ddNus
[主题词] Dideoxynucleosides
[药动学] Reverse Transcriptase Inhibitors
[英文释义] Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.